中文
Diisopropylazodicarboxylate (DIAD) is an organic compound with the chemical formula C ₈ H ₁ N ₂ O ₄ and a molecular weight of approximately 202.2. The appearance is an orange red transparent oily liquid with a special odor. It is soluble in common organic solvents such as ethanol and acetone, but insoluble in water. It has good thermal stability and is not easily decomposed at room temperature, but it should be avoided from contact with oxides and stored in a cool and ventilated place away from light.
DIAD plays a key role in multiple fields:
Organic synthesis: As the core reagent of Mitsunobu reaction (photopolymerization reaction), it can efficiently convert alcohols into esters, ethers and other derivatives under mild conditions, and is widely used in the synthesis of drugs and fine chemicals. For example, in the molecular construction of anticancer drugs and antibiotics, DIAD helps to accurately form chiral centers and improve reaction efficiency.
Material science: used as a liquid foaming agent for vinyl resin, it can prepare light colored foamed plastics to produce uniform microporous structure, suitable for closed or open cell foam bodies, and the decomposition products are non-toxic and do not pollute the environment.
Other fields: It also has applications in proteomics and anomaly detection, promoting biomedical research.
Safety and Storage
DIAD belongs to the GHS hazardous classification substance, which has skin and eye irritation and may cause cancer. Protective equipment should be worn during operation. When storing, it is necessary to maintain a low temperature (2-8 ° C), keep away from sources of fire and oxidants, and ensure good ventilation in the environment. Caution should be exercised in handling leaks to avoid contact with skin or inhalation of vapors.
DIAD, with its multifunctionality, has become an invisible driving force in chemical synthesis and material development, continuously promoting cutting-edge technological innovation.