中文
In the synthesis of pharmaceutical intermediates, polysaccharide modification and finechemical sulfonation processes, pyridinesulfur trioxide complex serves as an excellent mildacting reagent that replaces traditional oleum and chlorosulfonic acid. Thanks to its stable coordination structure and controllable reactivity, it effectively addresses the drawbacks of conventional sulfonating reagents, such as violent reactions, susceptibility to damaging sensitive functional groups and abundant byproducts. It is now a highlyrecognized core raw material in the global finesynthesis sector. Public overseas chemical industry data indicates that over 60 % of market demand for this product stems from biopharmaceutical R&D and industrialscale production scenarios.
Pyridinesulfur trioxide complex (CAS: 26412873), molecular formula C₅H₅NO₃S, molecular weight 159.16, fully complies with authoritative international chemicalquality control standards from Merck, TCI and other institutions. It appears as a white crystalline powder; the general industrialgrade purity is ≥ 97 %, with stable active sulfur trioxide content. Its melting point ranges from 154 ℃ to 170 ℃. Insoluble in water and alcohols, it dissolves in polar organic solvents including DMF and DMSO. Chemically stable and nonvolatile, it is suitable for both precisionsynthesis laboratory experiments and massproduction processes.
Based on the classic ParikhDoering reaction system, this reagent features mild reaction conditions, superior selectivity and high functionalgroup compatibility. It enables precise sulfuricacid esterification of alcohols and sulfation modification of hyaluronic acid and fungal polysaccharides. It is also widely used in the synthetic preparation of steroidal drugs and naturalactive intermediates. It can preserve the active structures of substrates to the maximum extent, improving finalproduct purity and bioavailability, and meeting the production requirements of highend fine chemicals.
Classified as Category 8 corrosive hazardous chemical, this product shall be shipped in strict accordance with the international transport specification UN 3261. It shall be stored in a sealed, dry and dark environment to prevent hydrolysisinduced performance degradation. Compliant storage and transportation are critical to guaranteeing product activity and quality.
Tengxiang Import & Export specializes in supplying fine pharmaceutical and chemical raw materials, with highquality pyridinesulfur trioxide complex as one of its main products. Ample stock and consistent batchtobatch performance are available, with all indicators benchmarked against international standards. The company maintains a complete qualityinspection system and compliant procedures for hazardouschemical import and export. It supports smallbatch laboratory trial orders as well as largevolume factory procurement, and delivers professional technical consultation, stable supply, onestop logistics and supporting services. With reliable quality, we assist customers at home and abroad in efficiently advancing diverse sulfonationsynthesis projects.