PPTS: High-Efficiency, Safe, and Easy-to-Use Catalyst – Essential for Laboratory Synthesis

Pyridinium p-toluenesulfonate (PPTS) is a commonly used organic synthesis catalyst that is not a strong acid but can effectively promote reactions. It is widely used in laboratories and small-scale production, featuring simple operation and low cost.
Advantages:
1. High catalytic efficiency, requiring only small amounts to facilitate smooth reactions and conserve usage.
2. The reaction conditions are mild and do not damage sensitive functional groups, making it suitable for the synthesis of pharmaceutical intermediates.
3. Unlike concentrated sulfuric acid, it has weaker corrosiveness, making it safer for equipment and operators.
4. Easy to separate; post-reaction removal can be achieved through simple filtration or water washing, reducing the need for additional processing steps.
5. Stable pricing, with a specification of 99% purity costing less than 1 yuan per gram, offering high cost performance.
Disadvantages:
1. It is prone to moisture absorption. Once opened, it must be sealed promptly to avoid caking and loss of efficacy.
2. It decomposes upon contact with water and cannot be used directly in aqueous systems; it must be handled in dry solvents.
3. The powder is slightly irritating. It is recommended to wear gloves and safety goggles during handling to avoid inhaling dust.
4. For use, simply add 0.1 to 0.5 equivalents based on reaction requirements, and proceed at room temperature or with slight heating. Commonly used in hydroxyl protection, deprotection, esterification, and condensation reactions. Suitable for university laboratories, pharmaceutical R&D, and small-scale fine chemical trials.